Asthenic conditions (fatigue, malaise, weakness)

61%

45%

Diarrhea

57%

21%

Nausea

57%

14%

Constipation

42%

15%

Peripheral neuropathy*

36%

9%

Vomiting

35%

6%

Fever

35%

16%

Thrombocytopenia

35%

11%

Psychiatric disorders

35%

49%

Decreased appetite or weight loss

34%

9%

Tingling sensation and impairment of sensitivity

27%

11%

Anemia

26%

22%

Headache

26%

13%

Cough

21%

11%

Grade 1* (paresthesias [sensations of numbness, tingling, or prickling], weakness, and/or loss of reflexes) without pain or loss of function

No action

Grade 1 with pain or Grade 2 (interfering with function but not with activities of daily living)

Reduce Velcade dose to 1.0 mg/m²

Grade 2 with pain or Grade 3 (interfering with activities of daily living)

Withhold Velcade therapy until toxicity resolves. When toxicity resolves, reinitiate with a reduced dose of Velcade at 0.7 mg/m² and change treatment schedule to once per week.

Grade 4 (permanent sensory loss that interferes with function, sensory neuropathy which is disabling, or motor neuropathy that is life threatening or leads to paralysis)

Discontinue Velcade