Bone marrow transplantation and chemotherapy can cure myeloma in some patients, but in most, the disease eventually returns because of drug-resistant myeloma cells. To eliminate drug-resistant cancer cells, we plan to activate patients? immune cells to recognize and kill myeloma cells. This will be achieved by injection of vectors that act as vaccine to boost immunity against myeloma cells. These activated immune cells called killer T lymphocytes will recognize the cancer proteins on myeloma cells and, as a result, kill the myeloma.