Multiple Myeloma is a cancer of the plasma cell, which is an important part of immune system. Plasma cells are derived from B cells, when B cells are damaged the plasma cells become malignant (grow unchecked). Malignant plasma cells travel through blood and migrate to the bone marrow where they damage tissue. This research proposal would investigate the mechanism by which heat shock protein 70 (HSP70) makes myeloma cells attach to bone marrow stromal cells, and resist programmed cell death (apoptosis). The mechanism by which attachment to stromal cells or interleukin 6 will increase production of HSP70 will be investigated. In addition, the role of HSP70 in cancer cell growth, and resistance to chemotherapy will be studied. Drugs, down regulating the HSP70 would potentially serve as suitable therapies specially when combined with other chemotherapy drugs against chemo sensitive and resistant myeloma.