Multiple myeloma is currently an incurable tumor that is sensitive to radiation therapy. Our laboratory has developed a virus based on the vaccine strain of measles virus that can preferentially infect myeloma cells and induce the expression of a normal thyroid protein that allows the cells to concentrate iodide isotopes. Myeloma tumors that are infected with the virus concentrate radio-iodine and are completely eradicated. We want to perform animal studies to evaluate the potential toxicity and fate of this virus before we can apply for a license with the Food and Drug Administration to proceed with a phase 1 clinical study for this disease.