Bone marrow transplantation and chemotherapy can cure myeloma in some patients, but in most, the disease eventually returns because of drug-resistant myeloma cells. To eliminate drug-resistant cancer cells, we plan to activate patientsŐ immune cells to recognize and kill myeloma cells. This will be achieved by expressing genes or proteins unique to cancer and myeloma in a subset of immune cells called dendritic cells. These dendritic cells can then be used to stimulate and activate other white blood cells, which will recognize the cancer proteins on myeloma cells and, as a result, kill the myeloma.