Defective gene expression is one of the underlying mechanisms leading to hematological malignancies. MMSET is a newly discovered gene that is involved in chromosomal abnormalities found in multiple myeloma and we hypothesize that its dysregulation may be responsible for some of the pathological features of this disease. We propose to characterize the MMSET protein and to determine whether it plays a role in the regulation of gene expression. This research may identify MMSET as a new target in the treatment of multiple myeloma.