Our laboratory previously showed that â1 integrin mediated signaling can confer drug resistance. In this proposal we provide preliminary data that â1 integrin inhibitory peptide referred to as HYD1 has anti-tumor activity as a single agent in vitro and in vivo. Furthermore the mechanism of cell death is independent of the activation of downstream caspases. The goals of this proposal are a) to delineate the mechanism of HYD1 induced cell death and b) determine optimal combination strategies for HYD1 treatment in multiple myeloma in vtro and in vivo.