Multiple Myeloma (MM) is a cancer involving cells that normally comprise a small population in the bone marrow. In this disease, however, certain changes in the genetic information of the cells cause them to multiply in number and become malignant. In our previous studies we have identified a genetic abnormality involving the Wnt signaling pathway that may be responsible for the disease progression. We have identified one such abnormality in many patients pointing to aberrant cellular processes responsible for the ability of the cancer cells to spread within and beyond the bone marrow microenvironment. We would like to develop short peptides to block the interaction between BCL9 and ƒÒ–catenin, a critical event for the activation of the Wnt pathway. We will validate these peptides in mice with the intent of developing therapies for future use in patients.