The Hsp90 molecule regulates the structure and function of several important proteins within the cells. Preliminary studies showed that novel drugs, which block the activity of Hsp90, can kill myeloma cells, overcome their resistance to conventional or novel therapies, and neutralize several mechanisms that promote their growth and survival in the bone microenvironment. Building on this preliminary work, the role of Hsp90 in the growth and survival of myeloma cells will be further investigated with the ultimate goal to provide the framework for novel therapies targeting the function of Hsp90.