Multiple Myeloma (MM) is a cancer involving cells that normally comprise a small population in the bone marrow. In this disease, however, certain changes in the genetic information of the cells causes them to multiply in number and become malignant, ultimately leading to extensive morbidity and mortality. At this time, there is no cure for MM and 90% of patients die within 10 years. We are working to find a cure for this devastating disease. In our previous studies we have found genetic abnormalities that may be responsible for the disease. We have identified one such abnormality in many patients pointing to aberrant cellular processes responsible for tumor growth and the ability of the cancer cells to home and spread within the bone marrow microenvironment. We would like to identify new and more specific drug targets within the Wnt signaling pathway, a cellular signaling pathway we have found to be dysregulated in MM cells. We will validate these drug targets in mice with the intent of developing therapies for future use in patients.