Multiple myeloma is an incurable cancer of the blood. Our laboratory is investigating a promising new treatment for this disease: cancer vaccines. The immune system finds and kills bacteria and viruses by molecular tags called “antigens.” Vaccines made with antigens stimulate immunity that kills microbes. We discovered that myeloma cells also have antigens that can be targeted by the immune system. We are testing myeloma antigen vaccines under laboratory conditions to determine if they can stimulate protective immunity against myeloma. These studies will lead to clinical trials in myeloma patients in the pursuit of long-term cures for this disease.