Multiple myeloma (MM) includes several closely related groups (diseases) that differ in clinical features, and response to therapy. Cell lines that can be grown in the laboratory provide a powerful tool for identifying the genetic abnormalities that cause MM, and also new therapies. Unfortunately, cell lines have been generated only from a fraction of advanced tumors, and some MM tumor groups are not represented by existing cell lines. We propose to put genes that facilitate survival and growth into MM tumor cells so that cell lines can be generated at a high efficiency from all kinds of MM tumors.