Myeloma is a cancer of bone marrow cells. Stem cell transplantation and chemotherapy can bring about remission, but myeloma eventually returns and is fatal. Mis-matched natural killer (NK) cells, given together with a patient’s own stem cells, exert an anti-myeloma effect. I will improve NK cell therapy by pre-treatment with modified stimulator cells, resulting in more NK cells that are also more lethal. I will also investigate whether certain drugs or a new myeloma-specific antibody can sensitize myeloma cells to killing by NK cells. Combining these strategies will make NK cell therapy highly effective, resulting in a cure for myeloma.