Multiple myeloma, produces proteins related to the immune system which results in kidney disease, bone destruction and decreased red blood cell number. We have developed a mouse antibody specific to a human blood protein, kininogen. Which antibody can decrease the growth of mouse myeloma cells, by preventing the formation of new blood vessels. We will reconstruct the mouse antibody to resemble a human antibody and determine how well the humanized antibody works against both mouse and human multiple myeloma. We will to determine the best doses and treatment schedules for the humanized antibody in mice and translate these to patients.